Found 56 of ec50 data for polymerid = 1180,1570,362,50006636,5066,5068,5461,6027,6028,6551,716,788,7940
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 7.90nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 8.70nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 9.5nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 17nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:cAMP elevation in U937 cellsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 37nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 42nMAssay Description:Relaxant effect on rabbit corpus cavernosal tissue stripsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Relaxant effect on rabbit corpus cavernosal tissue stripsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 130nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 220nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 220nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
University Of Hyderabad Campus
Curated by ChEMBL
University Of Hyderabad Campus
Curated by ChEMBL
Affinity DataEC50: 220nMAssay Description:Inhibition of PDE4B expressed in HEK293 cells assessed as fold reduction in forskolin-stimulated cAMP production pretreated for 30 mins measured 4 hr...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 230nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 250nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 250nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 270nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 280nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 330nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 480nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 500nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 500nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 500nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 500nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 630nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 700nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 830nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
University Of Hyderabad Campus
Curated by ChEMBL
University Of Hyderabad Campus
Curated by ChEMBL
Affinity DataEC50: 890nMAssay Description:Inhibition of PDE4B expressed in HEK293 cells assessed as fold reduction in forskolin-stimulated cAMP production pretreated for 30 mins measured 4 hr...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 900nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 910nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:cAMP elevation in U937 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.61E+3nMAssay Description:Inhibition of human PDE4D in U937 cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 2.10E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 3.30E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 3.40E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 4.10E+3nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 4.60E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 5.05E+3nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
University Of Glasgow
Curated by ChEMBL
University Of Glasgow
Curated by ChEMBL
Affinity DataEC50: 5.60E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 5.81E+3nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 6.70E+3nMAssay Description:Inhibition of PDE5A in HEK293 cells stably transfected with cGMP biosensor assessed as increase in SNP-induced intracellular cGMP level measured afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataEC50: 6.80E+3nMAssay Description:Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substrate by HPLC analysis relative to sildenafilMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human recombinant PDE4D2 using [3H]cAMP as substrate measured after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Rti International
Curated by ChEMBL
Rti International
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human recombinant PDE3A using [3H]cAMP as substrate measured after 15 mins by scintillation counting analysisMore data for this Ligand-Target Pair